Video Presentation - VT40

BPES : Integrating Historical, Genetic, and Surgical Perspectives with Institutional
Experience

Blepharophimosis–Ptosis–Epicanthus Inversus Syndrome (BPES) is a complex congenital
disorder characterized by distinct eyelid anomalies and genetic heterogeneity. This video
reviews the evolution of BPES understanding, highlighting key genetic mutations such as
FOXL2, along with modifier genes like UBE3B and KAT6B. It demonstrates contemporary
surgical approaches, including medial canthoplasty and frontalis suspension, tailored to
individual phenotypes. Institutional data analysis reveals female predominance, bilateral
involvement, satisfactory symmetry, and low revision rates. Emphasis is placed on choosing
between one-stage and two-stage corrections based on clinical presentation. 
Conclusion- By integrating molecular insights with customized surgical planning, this video underscores the importance
of a multidisciplinary approach in optimizing functional and cosmetic outcomes in BPES
management.